The main difference between Odif Basting Spray in the yellow can and the red can is the strength of the adhesive. The yellow can is formulated with a temporary adhesive that allows you to reposition your fabric as needed before permanently fixing it in place. The red can, on the other hand, is formulated with a stronger adhesive that provides a more permanent hold and is better suited for larger or heavier fabrics. Ultimately, the choice between the two will depend on your specific project needs and desired level of adhesion.